Cerebral venous sinus thrombosis (CVST) and hyperlipidemia are severe complications of L-Asparaginase (L-Asp) during the treatment of B-cell acute lymphoblastic leukemia (B-ALL).Herein, we reported a 9-year-old B-ALL boy who underwent abnormal hypertriglyceridemia and CVST presenting as seizures and disturbance of consciousness twice during the induction read more therapy.Fortunately, he survived treatment with anticoagulant and lipid-lowering therapy.No thrombophilia-related gene mutation was detected, but aluminum lotion a heterozygous mutation in lipoprotein lipase (LPL) gene was identified.
His neurological symptoms were managed with short-term anticoagulant therapy and long-term lipid-lowering therapy.This case illustrated the manifestation and potential pathogenesis of CVST and highlighted the essentiality of screening baseline lipid profile and dyslipidemia- and thrombophilia-related gene mutation.